medical school

 

  Glanzmann's thrombasthenia is a rare inherited bleeding disorder caused by a defect in the platelet integrin αIIbβ3, which affects platelet aggregation. Treatment generally focuses on managing bleeding episodes and preventing excessive bleeding. Here are some of the common treatment options: Platelet Transfusions : In cases of significant bleeding or prior to surgery, platelet transfusions can provide the missing platelet function. Desmopressin (DDAVP) : This medication can increase the release of von Willebrand factor and factor VIII, which might help improve platelet function in some patients with mild forms of Glanzmann's thrombasthenia. Antifibrinolytic Therapy : Drugs like tranexamic acid or aminocaproic acid may be used to prevent the breakdown of blood clots, especially during dental procedures or surgery. Recombinant Activated Factor VII (rFVIIa) : In cases of severe bleeding, rFVIIa can be used to help promote clotting in the absence of normal platelet aggregation. G...